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The child is father to the man: Developmental roles for proteins of importance for neurodegenerative disease
Author(s) -
Rogers Danny,
Schor Nina F.
Publication year - 2010
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21841
Subject(s) - neurodegeneration , neuroscience , disease , cell fate determination , oxidative stress , biology , pathogenesis , neural stem cell , parkinson's disease , programmed cell death , degenerative disease , stem cell , medicine , central nervous system disease , genetics , immunology , pathology , apoptosis , transcription factor , gene , endocrinology
Although Alzheimer's and Parkinson's diseases predominately affect elderly adults, the proteins that play a role in the pathogenesis of these diseases are expressed throughout life. In fact, many of the proteins hypothesized to be important in the progression of neurodegeneration play direct or indirect roles in the development of the central nervous system. The systems affected by these proteins include neural stem cell fate decisions, neuronal differentiation, cellular migration, protection from oxidative stress, and programmed cell death. Insights into the developmental roles of these proteins may ultimately impact the understanding of neurodegenerative diseases and lead to the discovery of novel treatments. ANN NEUROL 2010;67:151–158