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Role of endogenous testosterone concentration in pediatric stroke
Author(s) -
Normann Sandra,
de Veber Gabrielle,
Fobker Manfred,
Langer Claus,
Kenet Gili,
Bernard Timothy J.,
Fiedler Barbara,
Sträter Ronald,
Goldenberg Neil A.,
NowakGöttl Ulrike
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21840
Subject(s) - medicine , odds ratio , testosterone (patch) , confidence interval , stroke (engine) , percentile , multivariate analysis , gastroenterology , endocrinology , mechanical engineering , statistics , mathematics , engineering
Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38–11.45]; AIS = 3.88 [1.13–13.35]; CSVT = 5.50 [1.65–18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3‐fold. Ann Neurol 2009;66:754–758