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Chronic inflammatory demyelinating polyneuropathy sera inhibit axonal growth of mouse dorsal root ganglion neurons by activation of rho‐kinase
Author(s) -
Taniguchi Junko,
Sawai Setsu,
Mori Masahiro,
Kubo Takekazu,
Kanai Kazuaki,
Misawa Sonoko,
Isose Sagiri,
Yamashita Toshihide,
Kuwabara Satoshi
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21784
Subject(s) - dorsal root ganglion , polyneuropathy , chronic inflammatory demyelinating polyneuropathy , medicine , ganglion , kinase , axonal degeneration , protein kinase a , dorsum , pathology , immunology , chemistry , neuroscience , microbiology and biotechnology , biology , anatomy , antibody
Clinical course and prognosis are variable among patients with chronic inflammatory demyelinating polyneuropathy (CIDP), whereas the extent of axonal degeneration is the major prognostic factor. We studied the effects of sera from CIDP patients on axonal growth in cultured mouse dorsal root ganglion neurons. Compared with control sera, CIDP sera prominently suppressed axonal outgrowth of dorsal root ganglion neurons and shortened axonal length. The inhibitory activity was abolished by adding Y27632, a Rho‐kinase inhibitor. These findings suggest that CIDP sera inhibit axonal elongation by Rho‐kinase activation, and some serum factors may be responsible for development of axonal degeneration in CIDP. Ann Neurol 2009;66:694–697