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A neural network critical for spelling
Author(s) -
Cloutman Lauren,
Gingis Leila,
Newhart Melissa,
Davis Cameron,
HeidlerGary Jennifer,
Crinion Jennifer,
Hillis Argye E.
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21693
Subject(s) - spelling , white matter , psychology , voxel , lateralization of brain function , neuroscience , agraphia , posterior parietal cortex , magnetic resonance imaging , functional magnetic resonance imaging , audiology , medicine , dyslexia , radiology , reading (process) , philosophy , linguistics , political science , law
We aimed to identify neuroanatomical regions associated with deficits to the graphemic buffer, a working memory component of the spelling system that holds the sequence of letter identities during production. We evaluated 331 patients with left hemisphere ischemic stroke with various spelling tests and magnetic resonance diffusion‐weighted imaging and perfusion‐weighted imaging, within 48 hours of stroke onset. A voxel‐wise statistical map showed that ischemia in voxels in posterior and inferior frontal and parietal cortex, subcortical white matter underlying prefrontal cortex, lateral occipital gyrus, or caudate was associated with impairment in maintaining the sequence of letter identities while spelling. Ann Neurol 2009;66:249–253