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SNCA variants are associated with increased risk for multiple system atrophy
Author(s) -
Scholz Sonja W.,
Houlden Henry,
Schulte Claudia,
Sharma Manu,
Li Abi,
Berg Daniela,
Melchers Anna,
Paudel Reema,
Gibbs J. Raphael,
SimonSanchez Javier,
PaisanRuiz Coro,
Bras Jose,
Ding Jinhui,
Chen Honglei,
Traynor Bryan J.,
Arepalli Sampath,
Zonozi Ryan R.,
Revesz Tamas,
Holton Janice,
Wood Nick,
Lees Andrew,
Oertel Wolfgang,
Wüllner Ullrich,
Goldwurm Stefano,
Pellecchia Maria Teresa,
Illig Thomas,
Riess Olaf,
Fernandez Hubert H.,
Rodriguez Ramon L.,
Okun Michael S.,
Poewe Werner,
Wenning Gregor K.,
Hardy John A.,
Singleton Andrew B.,
Gasser Thomas
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21685
Subject(s) - single nucleotide polymorphism , odds ratio , snp , atrophy , genome wide association study , case control study , genetic association , synucleinopathies , genetics , medicine , disease , biology , parkinson's disease , bioinformatics , genotype , gene , alpha synuclein
To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome‐wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 × 10 12 ; odds ratio 6.2). Ann Neurol 2009;65:610–614