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What sort of change to believe in: An alternate opinion
Author(s) -
Fink David J.,
Albin Roger L.
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21669
Subject(s) - annals , neurology , clinical neurology , service (business) , associate editor , citation , psychology , medicine , classics , library science , computer science , history , psychiatry , neuroscience , economy , economics
ronal circuits is admittedly not well known. Single-cell recording may show several phases of inhibition-excitation or the reverse in response to afferent stimulation in the normal thalamus. This is a feature of many basal ganglia nuclei and does not preclude a global excitatory or inhibitory alteration occurring in pathological states. Overall, the evidence for increased basal ganglia output activity in the parkinsonian state remains compelling. Clearly, the pathophysiology of the basal ganglia changes that occur in PD have not been completely elucidated, and it is important to remain open to new findings and ideas. However, we do not believe that the findings that Montgomery provided yet warrant abandoning our fundamental concepts.