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Decreased ventilatory response to hypercapnia in dementia with Lewy bodies
Author(s) -
Mizukami Katsuyoshi,
Homma Toshiaki,
Aonuma Kazutaka,
Kinoshita Toru,
Kosaka Kenji,
Asada Takashi
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21613
Subject(s) - dementia with lewy bodies , hypercapnia , medicine , orthostatic vital signs , autonomic function , cardiology , heart rate variability , dementia , respiratory system , anesthesia , disease , heart rate , blood pressure
A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low uptake on 123 I‐metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB. Ann Neurol 2009;65:614–617