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Detection of isolated cerebrovascular β‐amyloid with pittsburgh compound B
Author(s) -
Greenberg Steven M.,
Grabowski Thomas,
Gurol M. Edip,
Skehan Maureen E.,
Nandigam R. N. Kaveer,
Becker John A.,
GarciaAlloza Monica,
Prada Claudia,
Frosch Matthew P.,
Rosand Jonathan,
Viswanathan Anand,
Smith Eric E.,
Johnson Keith A.
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21528
Subject(s) - pittsburgh compound b , cerebral amyloid angiopathy , positron emission tomography , amyloid (mycology) , pathology , alzheimer's disease , medicine , white matter , neuroimaging , cerebral cortex , magnetic resonance imaging , neuroscience , psychology , disease , nuclear medicine , dementia , radiology , psychiatry
Imaging of cerebrovascular β‐amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42‐year‐old man with early manifestations of Iowa‐type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar β‐amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions. Ann Neurol 2008;64:587–591