Premium
Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
Author(s) -
Sonnen Joshua A.,
Larson Eric B.,
Gray Shelly L.,
Wilson Angela,
Kohama Steven G.,
Crane Paul K.,
Breitner John C. S.,
Montine Thomas J.
Publication year - 2009
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21508
Subject(s) - medicine , alzheimer's disease , disease , neuroscience , cerebral cortex , clinical trial , free radical theory of aging , cortex (anatomy) , pathology , psychology , oxidative stress
Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should consider other antioxidants or doses than those identified in our study. Ann Neurol 2009;65:226–229