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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
Author(s) -
Ross Owen A.,
Wu YihRu,
Lee MeiChing,
Funayama Manabu,
Chen MengLing,
Soto Alexandra I.,
Mata Ignacio F.,
LeeChen GueyJen,
Chen Chiung Mei,
Tang Michelle,
Zhao Yi,
Hattori Nobutaka,
Farrer Matthew J.,
Tan EngKing,
Wu RueyMeei
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21405
Subject(s) - lrrk2 , odds ratio , disease , parkinson's disease , risk factor , haplotype , confidence interval , medicine , oncology , genetics , biology , genotype , gene
Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine‐rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20–2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008