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Predicting progression in primary progressive multiple sclerosis: A 10‐year multicenter study
Author(s) -
Khaleeli Zhaleh,
Ciccarelli Olga,
Manfredonia Francesco,
Barkhof Frederik,
Brochet Bruno,
Cercignani Mara,
Dousset Vincent,
Filippi Massimo,
Montalban Xavier,
Polman Chris,
Rovaris Marco,
Rovira Alex,
SastreGarriga Jaume,
Vellinga Machteld,
Miller David,
Thompson Alan
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21375
Subject(s) - expanded disability status scale , multiple sclerosis , medicine , logistic regression , disease , ordered logit , physical therapy , pediatrics , psychiatry , statistics , mathematics
Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long‐term disability provide some insight into disease progression. Ann Neurol 2008