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Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: A pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma
Author(s) -
Porter Alyx B.,
Giannini Caterina,
Kaufmann Timothy,
Lucchinetti Claudia F.,
Wu Wenting,
Decker Paul A.,
Atkinson John L. D.,
O'Neill Brian Patrick
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21366
Subject(s) - medicine , primary central nervous system lymphoma , corticosteroid , biopsy , lymphoma , central nervous system , retrospective cohort study , brain biopsy , surgery , radiology , pathology
The objective is to determine whether corticosteroid administration before biopsy prevents histopathological diagnosis of primary central nervous system lymphoma (PCNSL). A retrospective review was performed of immunocompetent PCNSL patients from 1985 to 2005. A total of 109 patients was identified. Sixty‐eight (63.6%) patients received corticosteroids before diagnosis. Thirteen patients (of 109; 12%) had undergone repeat brain biopsy to confirm PCNSL. These included 8 (of 68) patients who had received corticosteroids (12%), and 5 (of 39) who had not (13%) ( p = 1.0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis. Ann Neurol 2008;63:662–667