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Autoimmune myelopathy associated with collapsin response‐mediator protein‐5 immunoglobulin G
Author(s) -
Keegan B. Mark,
Pittock Sean J.,
Len Vanda A.
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21324
Subject(s) - myelopathy , medicine , transverse myelitis , pathology , occult , serology , mediator , multiple sclerosis , immunology , antibody , spinal cord , psychiatry , alternative medicine
Several autoimmune myelopathies are recognized clinically. We describe 57 patients in whom serological evaluation for myelopathy of uncertain cause demonstrated collapsin response‐mediator protein 5 IgG. Most had spinal imaging and cerebrospinal fluid abnormalities and insidiously progressive presentation; some had acute monophasic or relapsing myelopathy. Initial diagnoses included multiple sclerosis, transverse myelitis, and unspecified neurodegenerative myelopathy. Most were smokers; neoplasia was discovered in 68% (most commonly small‐cell lung carcinoma and after collapsin response‐mediator protein‐5 IgG detection). Collapsin response‐mediator protein‐5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk. Ann Neurol 2008