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Memory enhancement induced by hypothalamic/fornix deep brain stimulation
Author(s) -
Hamani Clement,
McAndrews Mary Pat,
Cohn Melanie,
Oh Michael,
Zumsteg Dominik,
Shapiro Colin M.,
Wennberg Richard A.,
Lozano Andres M.
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21295
Subject(s) - fornix , stimulation , deep brain stimulation , neuroscience , hippocampus , temporal lobe , psychology , recall , episodic memory , brain stimulation , limbic system , amygdala , lateral hypothalamus , medicine , cognitive psychology , epilepsy , central nervous system , cognition , disease , parkinson's disease
Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double‐blinded “on” versus “off” manner demonstrated that stimulation increased recollection but not familiarity‐based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions. Ann Neurol 2008;63:119–123