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Cutaneous allodynia in the migraine population
Author(s) -
Lipton Richard B.,
Bigal Marcelo E.,
Ashina Sait,
Burstein Rami,
Silberstein Stephen,
Reed Michael L.,
Serrano Daniel,
Stewart Walter F.
Publication year - 2008
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21211
Subject(s) - odds ratio , allodynia , confidence interval , medicine , migraine , population , checklist , anesthesia , physical therapy , hyperalgesia , psychology , nociception , receptor , environmental health , cognitive psychology
Objective To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population. Methods Migraineurs (n = 11,388) completed the Allodynia Symptom Checklist, assessing the frequency of allodynia symptoms during headache. Response options were never (0), rarely (0), less than 50% of the time (1), ≥50% of the time (2), and none (0). We used item response theory to explore how well each item discriminated CA. The relations of CA to headache features were examined. Results All 12 questions had excellent item properties. The greatest discrimination occurred with CA during “taking a shower” (discrimination = 2.54), wearing a necklace (2.39) or ring (2.31), and exposure to heat (2.1) or cold (2.0). The factor analysis demonstrated three factors: thermal, mechanical static, and mechanical dynamic. Based on the psychometrics, we developed a scale distinguishing no CA (scores 0–2), mild (3–5), moderate (6–8), and severe (≥9). The prevalence of allodynia among migraineurs was 63.2%. Severe CA occurred in 20.4% of migraineurs. CA was associated with migraine defining features (eg, unilateral pain: odds ratio, 2.3; 95% confidence interval, 2.0–2.4; throbbing pain: odds ratio, 2.3; 95% confidence interval, 2.1–2.6; nausea: odds ratio, 2.3; 95% confidence interval, 2.1–2.6), as well as illness duration, attack frequency, and disability. Interpretation The Allodynia Symptom Checklist measures overall allodynia and subtypes. CA affects 63% of migraineurs in the population and is associated with frequency, severity, disability, and associated symptoms of migraine. CA maps onto migraine biology. Ann Neurol 2007