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Age‐related changes in reading systems of dyslexic children
Author(s) -
Shaywitz Bennett A.,
Skudlarski Pawel,
Holahan John M.,
Marchione Karen E.,
Constable R. Todd,
Fulbright Robert K.,
Zelterman Daniel,
Lacadie Cheryl,
Shaywitz Sally E.
Publication year - 2007
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21093
Subject(s) - dyslexia , reading (process) , psychology , audiology , developmental psychology , cognitive psychology , medicine , linguistics , philosophy
Objective To examine age‐related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents. Methods Functional magnetic resonance imaging was used to study age‐related changes in the neural systems for reading in a cross‐sectional sample of 232 right‐handed children 7 to 18 years of age (113 dyslexic readers and 119 nonimpaired readers) as they read pseudowords. Results In nonimpaired readers, systems in the left anterior lateral occipitotemporal area developed with age, whereas systems in the right superior and middle frontal regions decreased. In contrast, in dyslexic readers, systems in the left posterior medial occipitotemporal regions developed with age. Older nonimpaired readers were left lateralized in the anterior lateral occipitotemporal area; there was no difference in asymmetry between younger and older dyslexic readers. Interpretation These findings offer a possible neurobiological explanation for the differences in reading acquisition between dyslexic and nonimpaired readers and provide further evidence of the critical role of the left occipitotemporal region in the development of reading. Ann Neurol 2007;61:363–370