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Genetics of Parkinson's disease and parkinsonism
Author(s) -
Hardy John,
Cai Huaiban,
Cookson Mark R.,
GwinnHardy Katrina,
Singleton Andrew
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.21022
Subject(s) - parkinsonism , disease , clinical practice , parkinson's disease , psychiatry , medicine , psychology , pathology , family medicine
Until 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600). Recently, these research findings have begun to impact clinical practice, and this impact is likely to increase. The primary purpose of this article is to outline these genetic advances, discuss their importance for current practice in clinical and related settings, and outline briefly how they are influencing research into the causes of and possible future treatments for this prevalent disorder. Ann Neurol 2006;60:389–398