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The neurobiology of neurooncology
Author(s) -
Read TracyAnn,
Hegedus Balazs,
WechslerReya Robert,
Gutmann David H.
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20912
Subject(s) - neurooncology , neuroscience , biology , central nervous system , pathogenesis , brain tumor , medicine , pathology
The histological classification of brain tumors currently is based on the morphological appearance and protein expression patterns that reflect specific cell types within the central nervous system. Recent studies have suggested that the cells of origin for brain tumors may persist in the fully formed tumors, and that these “cancer stem cells” might represent the relevant cellular targets for anticancer therapy. In this regard, insights into the developmental neurobiology of brain tumors has significant impact on our understanding of the molecular and cellular pathogenesis of these devastating cancers, as well as the development of new strategies for treating brain tumors. Ann Neurol 2006;60:3–11