Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis | Zendy

Thacker Evan L. | Zendy; Mirzaei Fariba | Zendy; Ascherio Alberto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis

Author(s) -

Thacker Evan L.,

Mirzaei Fariba,

Ascherio Alberto

Publication year - 2006

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.20820

Subject(s) - mononucleosis , multiple sclerosis , medicine , confidence interval , meta analysis , epstein–barr virus infection , cohort study , risk factor , relative risk , epstein–barr virus , cohort , case control study , immunology , virus , pediatrics

Objective To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein–Barr virus infection after childhood, and the risk for multiple sclerosis (MS).Methods We conducted a systematic review and meta‐analysis of case–control and cohort studies of IM and MS.Results The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7–3.0; p < 10 −8 ). Potential sources of heterogeneity (ie, study design, MS definition, and latitude) barely influenced our results.Interpretation We conclude that Epstein–Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS. Ann Neurol 2006; 59:499–503

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research