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Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis
Author(s) -
Weinshenker Brian G.,
Wingerchuk Dean M.,
Vukusic Sandra,
Linbo Linda,
Pittock Sean J.,
Lucchinetti Claudia F.,
Len Vanda A.
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20770
Subject(s) - transverse myelitis , neuromyelitis optica , optic neuritis , myelitis , medicine , magnetic resonance imaging , pathology , multiple sclerosis , radiology , spinal cord , immunology , psychiatry
Objective We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis.Methods Prospective study of patients with initial LETM who were tested for the presence of NMO‐IgG.Results Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis ( p = 0.004).Interpretation LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO‐IgG are at high risk for relapse. Ann Neurol 2006