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Increased midbrain gray matter in Tourette's syndrome
Author(s) -
Garraux Gaëtan,
Goldfine Andrew,
Bohlhalter Stephan,
Lerner Alicja,
Hanakawa Takashi,
Hallett Mark
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20765
Subject(s) - midbrain , tourette syndrome , gray (unit) , voxel based morphometry , psychology , neuroscience , medicine , magnetic resonance imaging , anatomy , psychiatry , white matter , central nervous system , nuclear medicine , radiology
Abstract Objective To investigate cerebral structure in Tourette's syndrome (TS). Methods Voxel‐based morphometry study of high‐resolution MRIs in 31 TS patients compared with 31 controls. Results Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508–514) according to which midbrain disturbances play an important pathogenic role in TS. Ann Neurol 2006;59:381–385