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Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: A multicentric Electroencephalogram study
Author(s) -
Babiloni Claudio,
Benussi Luisa,
Binetti Giuliano,
Cassetta Emanuele,
Dal Forno Gloria,
Del Percio Claudio,
Ferreri Florinda,
Ferri Raffaele,
Frisoni Giovanni,
Ghidoni Roberta,
Miniussi Carlo,
Rodriguez Guido,
Romani Gian Luca,
Squitti Rosanna,
Ventriglia Maria Carla,
Rossini Paolo M.
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20724
Subject(s) - electroencephalography , alpha (finance) , apolipoprotein e , psychology , beta rhythm , audiology , alzheimer's disease , alpha rhythm , beta (programming language) , neuroscience , rhythm , medicine , disease , developmental psychology , construct validity , computer science , programming language , psychometrics
Objective Relationships between the apolipoprotein E ε4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer's disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of ε4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods We enrolled 89 MCI subjects (34.8% with ε4) and 103 AD patients (50.4% with ε4). Resting eyes‐closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2—4Hz), theta (4–8Hz), alpha 1 (8–10.5Hz), alpha 2 (10.5–13Hz), beta 1 (13–20Hz), and beta 2 (20–30Hz). EEG cortical sources were estimated by low‐resolution brain electromagnetic tomography. Results Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the ε4 allele than in those not carrying the ε4 allele ( p < 0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation Such a demonstration motivates future genotype–EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects. Ann Neurol 2005