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Rapid eye movement sleep behavior disorder and potassium channel antibody–associated limbic encephalitis
Author(s) -
Iranzo Alex,
Graus Francesc,
Clover Linda,
Morera Jaume,
Bruna Jordi,
Vilar Carlos,
MartínezRodriguez José Enrique,
Vincent Angela,
Santamaría Joan
Publication year - 2006
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20693
Subject(s) - limbic encephalitis , rapid eye movement sleep , limbic system , neuroscience , potassium channel , medicine , voltage gated potassium channel , encephalitis , eye movement , psychology , immunology , central nervous system , virus
Of six patients registered in our center with nonparaneoplastic limbic encephalitis associated with antibodies to voltage‐gated potassium channels, the five men had rapid eye movement sleep behavior disorder (RBD) coincident with voltage‐gated potassium channel antibody–associated limbic encephalitis onset. In three patients, immunosuppression resulted in resolution of RBD in parallel with remission of the limbic syndrome. RBD persisted in two patients with partial resolution of the limbic syndrome. Our findings suggest that RBD is frequent in the setting of voltage‐gated potassium channel antibody–associated limbic encephalitis and can be related to autoimmune‐mediated mechanisms. In addition, these observations suggest that impairment of the limbic system may play a role in the pathogenesis of RBD. Ann neurol 2006