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Common variants of LRRK2 are not associated with sporadic Parkinson's disease
Author(s) -
Biskup Saskia,
Mueller Jakob C.,
Sharma Manu,
Lichtner Peter,
Zimprich Alexander,
Berg Daniela,
Wüllner Ullrich,
Illig Thomas,
Meitinger Thomas,
Gasser Thomas
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20664
Subject(s) - lrrk2 , parkinsonism , disease , genetics , mendelian inheritance , parkinson's disease , single nucleotide polymorphism , degenerative disease , mutation , gene , biology , medicine , genotype
Multiple mutations in the gene for the leucine‐rich repeat kinase ( LRRK2 ) cause autosomal dominant late‐onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non‐Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson's disease patients and 680 matched control subjects from Germany. No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson's disease risk. Ann Neurol 2005