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Resolution of EBV + CNS lymphoma with appearance of CSF EBV‐specific T cells
Author(s) -
de Beukelaar Janet W.,
van Arkel Cornelis,
van den Bent Martin J.,
van 't Veer Mars B.,
van Doornum Gerard J.,
Cornelissen Jan J.,
Sillevis Smitt Peter A.,
Gratama Jan W.
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20640
Subject(s) - cd8 , epstein–barr virus , lymphoma , immunology , major histocompatibility complex , virus , cerebrospinal fluid , biology , lymphoproliferative disorders , central nervous system , t cell , antigen , virology , medicine , pathology , immune system , neuroscience
Current knowledge of Epstein–Barr virus (EBV)–specific T‐cell responses in the cerebrospinal fluid (CSF) of patients with EBV‐related lymphoproliferative disease (EBV‐LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV‐LPD in the CNS. EBV‐specific CD8 + T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV‐derived peptides. The appearance of EBV‐specific CD8 + T cells in CSF and blood correlated with neurological improvement and disappearance of EBV‐LPD. These observations suggest a role for EBV‐specific CD8 + T cells in the control of EBV‐LPD in the CNS. Ann Neurol 2005;58:788–792