Premium
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Author(s) -
Aarsland Dag,
Perry Robert,
Brown Andrew,
Larsen Jan P.,
Ballard Clive
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20635
Subject(s) - neuropathology , lewy body , dementia , parkinson's disease , cognitive decline , dementia with lewy bodies , lewy body disease , psychology , disease , medicine , alzheimer's disease
Twenty‐two patients with Parkinson's disease drawn from a community‐based study were followed prospectively until their deaths. Even though 18 patients had dementia, none fulfilled Braak and Braak or The National Institute on Aging and Ronald and Nancy Reagan Institute of the Alzheimer's Association, whereas all patients had limbic or neocortical Lewy body disease. The Lewy body score and Braak and Braak stage were significantly associated with the rate of cognitive decline, but only the Lewy body score was associated with the rate of cognitive decline in the univariate analyses. This study strongly suggests that Lewy body disease is the main substrate driving the progression of cognitive impairment in Parkinson's disease. Ann Neurol 2005;58:773–776