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Functional recovery after embolic stroke in rodents by activated protein C
Author(s) -
Zlokovic Berislav V.,
Zhang Chunling,
Liu Dong,
Fernandez Jose,
Griffin John H.,
Chopp Michael
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20602
Subject(s) - embolic stroke , stroke (engine) , cardiology , medicine , physical medicine and rehabilitation , neuroscience , ischemic stroke , psychology , ischemia , mechanical engineering , engineering
A serine protease activated protein C has been shown to be a powerful neuroprotectant in stressed neurons and in hypoxic brain endothelium. In a clinically relevant model of embolic stroke in rodents, we now show that administration of activated protein C alone or in combination with tissue plasminogen activator, or both, 4 hours after embolic stroke improves the functional outcome and reduces brain infarction within 7 days of stroke. In contrast, tissue plasminogen activator alone was not protective. Thus, activated protein C may be useful as a new stand‐alone therapy for clinical stroke and to extend the time window of thrombolytic therapy. Ann Neurol 2005;58:474–477