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Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
Author(s) -
Rosand Jonathan,
Muzikansky Alona,
Kumar Ashok,
Wisco Jonathan J.,
Smith Eric E.,
Betensky Rebecca A.,
Greenberg Steven M.
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20596
Subject(s) - cerebral amyloid angiopathy , asymptomatic , intracerebral hemorrhage , medicine , gradient echo , occipital lobe , temporal lobe , pathology , magnetic resonance imaging , radiology , cardiology , dementia , disease , psychiatry , subarachnoid hemorrhage , epilepsy
Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient‐echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA–related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe ( p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA–related hemorrhage. Ann Neurol 2005;58:459–462