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Phosphodiesterase 4D and 5‐lipoxygenase activating protein in ischemic stroke
Author(s) -
Meschia James F.,
Brott Thomas G.,
Brown Robert D.,
Crook Richard,
Worrall Bradford B.,
Kissela Brett,
Brown W. Mark,
Rich Stephen S.,
Case L. Douglas,
Evans E. Whitney,
Hague Stephen,
Singleton Andrew,
Hardy John
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20585
Subject(s) - phosphodiesterase , lipoxygenase , stroke (engine) , ischemic stroke , medicine , cardiology , chemistry , enzyme , biochemistry , ischemia , mechanical engineering , engineering
Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D ( PDE4D ) and 5‐lipoxygenase activating protein ( ALOX5AP ). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP . Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single‐nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations. Ann Neurol 2005;58:351–361