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Positron emission tomography after fetal transplantation in Huntington's disease
Author(s) -
Furtado Sarah,
Sossi Vesna,
Hauser Roberta A.,
Samii Ali,
Schulzer Michael,
Murphy Colleen B.,
Freeman Thomas B.,
Stoessl A. Jon
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20564
Subject(s) - positron emission tomography , transplantation , medicine , huntington's disease , fetal tissue transplantation , striatum , fetus , disease , dopamine , oncology , nuclear medicine , biology , pregnancy , genetics
H untington's disease (HD) is a progressive disorder with no known cure. We report two‐year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. D1 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation. Ann Neurol 2005;58:331–337