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Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment
Author(s) -
Yao Yuemang,
Clark Christopher M.,
Trojanowski John Q.,
Lee Virginia M.Y.,
Praticò Domenico
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20558
Subject(s) - lipid peroxidation , lipoxygenase , cerebrospinal fluid , pathogenesis , cognitive impairment , dementia , medicine , alzheimer's disease , tau protein , endocrinology , enzyme , disease , psychology , neuroscience , oxidative stress , biochemistry , chemistry
The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathologically affected frontal and temporal regions of Alzheimer's disease (AD) brains compared with controls. Herein, we measured 12(S)‐HETE and 15(S)‐HETE levels, products of 12/15LOX, in cerebrospinal fluid (CSF) of normal individuals, subjects with mild cognitive impairment (MCI) and AD. Compared with controls, there was a significant increase of both metabolites in CSF from AD and MCI, which correlated with lipid peroxidation and tau protein levels. These results suggest that the activation of this enzyme occurs early in the course of AD, before the onset of overt dementia, thereby implicating 12/15LOX‐mediated lipid peroxidation in the pathogenesis of AD. Ann Neurol 2005