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Chromosome 1p loss: A favorable prognostic factor in low‐grade gliomas
Author(s) -
Kujas Michèle,
Lejeune Julie,
BenouaichAmiel Alexandra,
Crinière Emmanuelle,
LaigleDonadey Florence,
Marie Yannick,
Mokhtari Karima,
Polivka Marc,
Bernier Michèle,
Chretien Fabrice,
Couvelard Anne,
Capelle Laurent,
Duffau Hugues,
Cornu Philippe,
Broët Philippe,
Thillet Joëlle,
Carpentier Antoine F.,
Sanson Marc,
HoangXuan Khê,
Delattre JeanYves
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20543
Subject(s) - loss of heterozygosity , biology , hazard ratio , multivariate analysis , histology , chromosome , glioma , oncology , epidermal growth factor receptor , proportional hazards model , tumor progression , medicine , cancer research , pathology , allele , gene , genetics , receptor , confidence interval
Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor ( EGFR ) gene amplification, and p53 expression was performed in a series of 131 low‐grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression‐free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression‐free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low‐grade gliomas. Ann Neurol 2005;58:322–326