Neuroprotection by the PGE 2  EP2 receptor in permanent focal cerebral ischemia | Zendy

Liu Dong | Zendy; Wu Liejun | Zendy; Breyer Richard | Zendy; Mattson Mark P. | Zendy; Andreasson Katrin | Zendy

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Neuroprotection by the PGE 2 EP2 receptor in permanent focal cerebral ischemia

Author(s) -

Liu Dong,

Wu Liejun,

Breyer Richard,

Mattson Mark P.,

Andreasson Katrin

Publication year - 2005

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.20461

Subject(s) - neuroprotection , nmda receptor , ischemia , excitotoxicity , hippocampal formation , neuroscience , medicine , prostaglandin e2 receptor , receptor , pharmacology , brain ischemia , anesthesia , biology , agonist

Recent studies suggest a neuroprotective function of the PGE 2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N ‐methyl‐ D ‐aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke. Ann Neurol 2005;57:758–761

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