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Neuroprotection by the PGE 2 EP2 receptor in permanent focal cerebral ischemia
Author(s) -
Liu Dong,
Wu Liejun,
Breyer Richard,
Mattson Mark P.,
Andreasson Katrin
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20461
Subject(s) - neuroprotection , nmda receptor , ischemia , excitotoxicity , hippocampal formation , neuroscience , medicine , prostaglandin e2 receptor , receptor , pharmacology , brain ischemia , anesthesia , biology , agonist
Recent studies suggest a neuroprotective function of the PGE 2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N ‐methyl‐ D ‐aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke. Ann Neurol 2005;57:758–761