Pallidal stimulation improves pantothenate kinase–associated neurodegeneration | Zendy

Castelnau Pierre | Zendy; Cif Laura | Zendy; Valente Enza Maria | Zendy; Vayssiere Nathalie | Zendy; Hemm Simone | Zendy; Gannau Amandine | Zendy; DiGiorgio Annalisa | Zendy; Coubes Philippe | Zendy

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Pallidal stimulation improves pantothenate kinase–associated neurodegeneration

Author(s) -

Castelnau Pierre,

Cif Laura,

Valente Enza Maria,

Vayssiere Nathalie,

Hemm Simone,

Gannau Amandine,

DiGiorgio Annalisa,

Coubes Philippe

Publication year - 2005

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.20457

Subject(s) - dystonia , neurodegeneration , globus pallidus , deep brain stimulation , medicine , stimulation , neuroscience , physical medicine and rehabilitation , psychology , basal ganglia , parkinson's disease , disease , central nervous system

Pantothenate kinase–associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long‐lasting improvement of their painful spasms, dystonia, and functional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients. Ann Neurol 2005;57:738–741

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