Premium
Identification of hippocampus‐related candidate genes for Alzheimer's disease
Author(s) -
Taguchi Keiko,
Yamagata Hidehisa D.,
Zhong Wangtao,
Kamino Kouzin,
Akatsu Hiroyasu,
Hata Ryuji,
Yamamoto Takayuki,
Kosaka Kenji,
Takeda Masatoshi,
Kondo Ikuko,
Miki Tetsuro
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20433
Subject(s) - single nucleotide polymorphism , gene , candidate gene , alzheimer's disease , biology , disease , genetics , hippocampus , polymorphism (computer science) , genotype , medicine , neuroscience
Abstract Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism (+9943T/C) in POU2F1 was most significantly associated with AD ( p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD. Ann Neurol 2005;57:585–588