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Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity
Author(s) -
Jokic Natasa,
Gonzalez de Aguilar JoseLuis,
Pradat PierreFrançois,
Dupuis Luc,
EchanizLaguna Andoni,
Muller André,
Dubourg Odile,
Seilhean Danielle,
Hauw JeanJacques,
Loeffler JeanPhilippe,
Meininger Vincent
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20420
Subject(s) - amyotrophic lateral sclerosis , atrophy , medicine , gene isoform , pathology , muscle atrophy , degenerative disease , neuroscience , biology , disease , gene , biochemistry
Nogo, a protein inhibiting axonal regeneration, exhibits a characteristic isoform‐specific pattern of expression in skeletal muscle of transgenic mice and patients with amyotrophic lateral sclerosis. Here, the increased levels of Nogo‐A or Nogo‐B in muscle biopsies of 15 amyotrophic lateral sclerosis patients significantly correlated with the severity of clinical disability and with the degree of muscle fiber atrophy. Nogo‐A immunoreactivity was observed selectively in atrophic slow‐twitch type I fibers. These results suggest that Nogo expression in muscle is a marker of amyotrophic lateral sclerosis severity. Ann Neurol 2005;57:553–556