Premium
Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD
Author(s) -
Pyle Angela,
Foltynie Thomas,
Tiangyou Watcharee,
Lambert Claire,
Keers Sharon M.,
Allcock Liesl M.,
Davison Jill,
Lewis Simon J.,
Perry Robert H.,
Barker Roger,
Burn David J.,
Chinnery Patrick F.
Publication year - 2005
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20417
Subject(s) - haplogroup , human mitochondrial dna haplogroup , disease , mitochondrial dna , parkinson's disease , genetics , population , medicine , haplotype , biology , allele , gene , environmental health
There is increasing evidence that genetic variants of mitochondrial DNA have an important role in the cause of idiopathic Parkinson's disease. We determined the mitochondrial DNA haplogroup of 455 Parkinson's disease cases, 185 Alzheimer's disease cases, and 447 healthy English control subjects. The UKJT haplogroup cluster was associated with a 22% reduction in population‐attributable risk for Parkinson's disease. There was no association between individual haplogroups or the UKJT cluster and Alzheimer's disease, confirming that the association with Parkinson's disease was disease specific and not a general effect seen in all neurodegenerative diseases. Ann Neurol 2005;57:564–567