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In vivo detection of microglial activation in frontotemporal dementia
Author(s) -
Cagnin Annachiara,
Rossor Martin,
Sampson Elizabeth L.,
MacKin Toby,
Banati Richard B.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20332
Subject(s) - frontotemporal lobar degeneration , frontotemporal dementia , microglia , pathology , neuroscience , positron emission tomography , dementia , medicine , binding potential , degeneration (medical) , in vivo , psychology , biology , disease , inflammation , microbiology and biotechnology
Using positron emission tomography and [ 11 C]( R )‐PK11195, a marker of “peripheral benzodiazepine sites” that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [ 11 C]( R )‐PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [ 11 C]( R )‐PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration. Ann Neurol 2004;56:894–897