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High tumor necrosis factor‐α in levels in cerebrospinal fluid of cobalamin‐deficient patients
Author(s) -
Scalabrino Giuseppe,
Carpo Marinella,
Bamonti Fabrizia,
Pizzinelli Simona,
D'Avino Carla,
Bresolin Nereo,
Meucci Giuseppe,
Martinelli Vittorio,
Comi Gian Carlo,
Peracchi Maddalena
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20325
Subject(s) - cobalamin , cerebrospinal fluid , tumor necrosis factor alpha , concomitant , medicine , tumor necrosis factor α , epidermal growth factor , endocrinology , homocysteine , pathology , vitamin b12 , receptor
We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)‐deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)‐α and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF‐α, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF‐α and a decrease in EGF‐levels. Ann Neurol 2004;56:886–890 An Erratum has been published for this article in Ann Neurol 57: 304, 2005 .