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Serum lipids and hippocampal volume: The link to Alzheimer's disease?
Author(s) -
Wolf Henrike,
Hensel Anke,
Arendt Thomas,
Kivipelto Miia,
Winblad Bengt,
Gertz HermannJosef
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20289
Subject(s) - hippocampal formation , disease , alzheimer's disease , neuroscience , medicine , psychology
Abstract The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High‐density lipoprotein cholesterol, but not low‐density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high‐density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease. Ann Neurol 2004;56:745–749