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Disturbed surround inhibition in focal hand dystonia
Author(s) -
Sohn Young H.,
Hallett Mark
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20270
Subject(s) - dystonia , transcranial magnetic stimulation , focal dystonia , neuroscience , physical medicine and rehabilitation , movement disorders , psychology , medicine , index finger , stimulation , anatomy , disease
Disturbances in surround inhibition could account for various movement disorders. Here we test the functional operation of surround inhibition in focal hand dystonia. Transcranial magnetic stimulation was set to be triggered by self‐initiated voluntary flexion of the index finger. During this movement, motor‐evoked potential amplitudes from the little finger muscle were significantly suppressed in healthy subjects but enhanced in dystonia patients. This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia. Ann Neurol 2004;56:595–599