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Functional significance of S6K overexpression in meningioma progression
Author(s) -
Surace Ezequiel I.,
Lusis Eriks,
Haipek Carrie A.,
Gutmann David H.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20201
Subject(s) - meningioma , medicine , neuroscience , psychology , pathology
One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase ( S6K ) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM‐Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy. Ann Neurol 2004