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Bilateral globus pallidus stimulation for Huntington's disease
Author(s) -
Moro Elena,
Lang Anthony E.,
Strafella Antonio P.,
Poon YuYan W.,
Arango Pablo M.,
Dagher Alain,
Hutchison William D.,
Lozano Andres M.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20183
Subject(s) - chorea , deep brain stimulation , stimulation , huntington's disease , globus pallidus , neuroscience , psychology , cerebral blood flow , medicine , physical medicine and rehabilitation , disease , basal ganglia , anesthesia , parkinson's disease , central nervous system
Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) was performed in a patient with Huntington's disease (HD) with severe chorea. Stimulation at 40 and 130Hz improved chorea. Stimulation at 130Hz slightly worsened bradykinesia overall, whereas 40Hz had little effect. A [ 15 O] H 2 O positron emission tomography showed increased regional cerebral blood flow in motor decision making and execution areas more evident at 40Hz. Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia. Ann Neurol 2004