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Is benign rolandic epilepsy genetically determined?
Author(s) -
Vadlamudi Lata,
Harvey A. Simon,
Connellan Mary M.,
Milne Roger L.,
Hopper John L.,
Scheffer Ingrid E.,
Berkovic Samuel F.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20153
Subject(s) - concordance , idiopathic generalized epilepsy , epilepsy , confidence interval , rolandic epilepsy , immunoglobulin e , medicine , immunology , psychiatry , antibody
Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0–0.4) for BRE compared with 0.7 (95% CI, 0.5–0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored. Ann Neurol 2004;56:129–132