Is benign rolandic epilepsy genetically determined? | Zendy

Vadlamudi Lata | Zendy; Harvey A. Simon | Zendy; Connellan Mary M. | Zendy; Milne Roger L. | Zendy; Hopper John L. | Zendy; Scheffer Ingrid E. | Zendy; Berkovic Samuel F. | Zendy

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Is benign rolandic epilepsy genetically determined?

Author(s) -

Vadlamudi Lata,

Harvey A. Simon,

Connellan Mary M.,

Milne Roger L.,

Hopper John L.,

Scheffer Ingrid E.,

Berkovic Samuel F.

Publication year - 2004

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.20153

Subject(s) - concordance , idiopathic generalized epilepsy , epilepsy , confidence interval , rolandic epilepsy , immunoglobulin e , medicine , immunology , psychiatry , antibody

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0–0.4) for BRE compared with 0.7 (95% CI, 0.5–0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored. Ann Neurol 2004;56:129–132

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