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The 14q restless legs syndrome locus in the French Canadian population
Author(s) -
Levchenko Anastasia,
Montplaisir JacquesYves,
Dubé MariePierre,
Riviere JeanBaptiste,
StOnge Judith,
Turecki Gustavo,
Xiong Lan,
Thibodeau Pascale,
Desautels Alex,
Verlaan Dominique J.,
Rouleau Guy A.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20140
Subject(s) - locus (genetics) , genetics , population , psychology , biology , demography , gene , sociology
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two‐point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome. Ann Neurol 2004;55:887–891