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Long‐term results of bilateral pallidal stimulation in Parkinson's disease
Author(s) -
Volkmann Jens,
Allert Niels,
Voges Jürgen,
Sturm Volker,
Schnitzler Alfons,
Freund HansJoachim
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20091
Subject(s) - deep brain stimulation , subthalamic nucleus , dopaminergic , stimulation , medicine , parkinson's disease , anesthesia , neuroscience , psychology , disease , dopamine
We followed up 11 patients for up to 5 years after bilateral pallidal deep brain stimulation for advanced Parkinson's disease. Dyskinesias remained significantly reduced until the last assessment. The initial improvement of off‐period motor symptoms and fluctuations, however, was not sustained and gradually declined. Beneficial effects of pallidal deep brain stimulation on activities of daily living in the on‐ and off‐period were lost after the first year. Replacement of pallidal electrodes into the subthalamic nucleus in four patients could restore the initial benefit of deep brain stimulation and allowed a significant reduction of dopaminergic drug therapy.