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Plasma amyloid β, apolipoprotein E, lacunar infarcts, and white matter lesions
Author(s) -
Van Dijk Ewoud J.,
Prins Niels D.,
Vermeer Sarah E.,
Hofman Albert,
Van Duijn Cornelia M.,
Koudstaal Peter J.,
Breteler Monique M.B.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20050
Subject(s) - white matter , cerebral amyloid angiopathy , medicine , apolipoprotein e , magnetic resonance imaging , population , hyperintensity , odds ratio , pathology , leukoaraiosis , confidence interval , lacunar stroke , dementia , cardiology , radiology , ischemia , disease , ischemic stroke , environmental health
Lacunar brain infarcts and cerebral white matter lesions are frequently observed on magnetic resonance imaging scans in elderly subjects. These lesions are also frequent in patient with cerebral amyloid angiopathy. We examined whether plasma amyloid β peptide (Aβ) levels are associated with lacunar infarcts and white matter lesions in the general population, and whether the apolipoprotein E (APOE) genotype modifies these associations. We studied 1,077 participants within the population‐based Rotterdam Scan Study, who were 60 to 90 years of age and free of dementia. Cross‐sectional associations were analyzed by regression models with adjustments for age, sex, creatinine levels, and hypertension. In APOE ε4 carriers, plasma Aβ levels were positively associated with lacunar infarcts and white matter lesions, whereas in noncarriers no associations were observed. Per standard deviation increase in Aβ 1‐40 and Aβ 1‐42 levels the odds ratios for lacunar infarcts were 1.72 (95% confidence interval [CI] = 1.22–2.43) and 1.93 (95% CI = 1.31–2.85), the periventricular white matter lesion grade increased by 0.32 (95% CI = 0.08–0.57) and 0.29 (95% CI = 0.00–0.57), and the subcortical white matter lesion volume increased by 0.48ml (95% CI = 0.04–0.91) and 0.24ml (95% CI = −0.27–0.75). Higher Aβ levels are associated with more lacunar infarcts and white matter lesions in elderly subjects who carry an APOE ε4 allele. Ann Neurol 2004