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Prion deposition in olfactory biopsy of sporadic Creutzfeldt–Jakob disease
Author(s) -
Tabaton Massimo,
Monaco Salvatore,
Cordone Maria Paola,
Colucci Monica,
Giaccone Giorgio,
Tagliavini Fabrizio,
Zanusso Gianluigi
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20038
Subject(s) - pathology , olfactory epithelium , disease , pathological , olfactory mucosa , biopsy , medicine , creutzfeldt jakob syndrome , prion protein , olfactory system , in vivo , degenerative disease , biology , psychiatry , microbiology and biotechnology
Abstract Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt–Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt–Jakob disease.