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Abnormal imitation‐related cortical activation sequences in Asperger's syndrome
Author(s) -
Nishitani Nobuyuki,
Avikainen Sari,
Hari Riitta
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.20031
Subject(s) - mirror neuron , premotor cortex , psychology , imitation , neuroscience , superior temporal sulcus , frontal lobe , primary motor cortex , occipital lobe , temporal lobe , supplementary motor area , intraparietal sulcus , parietal lobe , cortex (anatomy) , motor cortex , audiology , posterior parietal cortex , functional magnetic resonance imaging , anatomy , medicine , epilepsy , dorsum , stimulation
Subjects with Asperger's syndrome (AS) are impaired in social interaction and imitation, but the underlying brain mechanisms are poorly understood. Because the mirror‐neuron system (MNS) that matches observed and executed actions has been suggested to play an important role in imitation and in reading of other people's intentions, we assessed MNS functions in 8 adult AS subjects and in 10 healthy control subjects during imitation of still pictures of lip forms. In the control subjects, cortical activation progressed in 30 to 80‐millisecond steps from the occipital cortex to the superior temporal sulcus, to the inferior parietal lobe, and to the inferior frontal lobe, and finally, 75 to 90 milliseconds later, to the primary motor cortex of both hemispheres. Similar activation sites were found in AS subjects but with slightly larger scatter. Activation of the inferior frontal lobe was delayed by 45 to 60 milliseconds and activations in the inferior frontal lobe and in the primary motor cortex were weaker than in control subjects. The observed abnormal premotor and motor processing could account for a part of imitation and social impairments in subjects with AS. Ann Neurol 2004