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Endocytic disturbances distinguish among subtypes of alzheimer's disease and related disorders
Author(s) -
Cataldo Anne,
Rebeck G. William,
Ghetti Bernadino,
Hulette Christine,
Lippa Carol,
Van Broeckhoven Christine,
Van Duijn Cornelia,
Cras Patrick,
Bogdanovic Nenad,
Bird Thomas,
Peterhoff Corrinne,
Nixon Ralph
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1254
Subject(s) - endocytic cycle , presenilin , alzheimer's disease , amyloid precursor protein , disease , neuroscience , amyloid (mycology) , biology , mutation , medicine , pathology , genetics , gene , endocytosis , cell , botany
The endocytic pathway is important in amyloid precursor protein (APP) processing and β‐amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerable regions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebral endothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased β‐amyloid generation in certain of these different Alzheimer's disease subtypes.